If you’ve spent any time in the corn, wheat, or barley farming space, you’ve likely encountered Pyroxsulam—our go-to for controlling tough broadleaf weeds and some grasses that refuse to die. As a Pyroxsulam supplier, I’ve talked to hundreds of farmers, agronomists, and input distributors who ask the same question: “What’s the right mixing ratio when I pair this with other chemicals?” It’s not a one-size-fits-all answer, but skipping this step means wasted product, poor weed control, or even crop damage. Over the past 8 years working with this herbicide, I’ve learned that the ratio hinges on three big factors: the target weed, the crop you’re protecting, and the other chemicals you’re combining it with. Let’s break this down like I would with a farmer standing in my warehouse, holding a bag of Pyroxsulam and a tank mix partner. Pyroxsulam
First, let’s get the basics on Pyroxsulam straight, because that’s where most mix-up starts. This is a member of the triazolopyrimidine class of herbicides, works by blocking acetolactate synthase (ALS), an enzyme weeds need to make amino acids. It’s systemic, so it gets absorbed through leaves and roots and moves through the entire weed, killing it from the inside out. It’s used mostly on small grains (wheat, barley, oats), corn (field and sweet), and even some grasses grown for seed. The standard solo application rate is 0.67 to 1.34 ounces of product per acre, but when you mix it with other chemicals, that base rate changes—sometimes a little, sometimes a lot.
The first and most critical variable: the target weed spectrum. If you’re dealing with lamb’s-quarters or pigweed, which are common and not super tough, Pyroxsulam alone will do the job at the low end of the range. But if you’re dealing with resistant biotypes, or weeds like kochia, waterhemp, or velvetleaf, you’ll need to pair Pyroxsulam with other actives to get full control, and that’s where ratios get tricky. For example, a lot of farmers mix Pyroxsulam with 2,4-D for broadleaf control in small grains. Let’s look at that tank mix. For spring wheat, if you’re targeting regular broadleaves, the standard mix is 0.8 oz Pyroxsulam per acre plus 1 pint of low-volatile 2,4-D amine (not ester, because ester can drift onto wheat heads and cause damage). But if you’re fighting resistant kochia, bump the Pyroxsulam up to 1.0 oz per acre and add 1.2 pints of 2,4-D. Wait, but some agronomists will also throw in dicamba for extra punch—there we adjust to 0.75 oz Pyroxsulam plus 4 oz of a low-rate dicamba product, because dicamba is more potent on tough weeds, so we don’t need as much Pyroxsulam to avoid crop stress.
Then there’s corn, which is another big use case. For field corn, Pyroxsulam is often mixed with atrazine, right? That’s a common combo for residual control too, not just post-emergent. For corn that’s 2 to 4 inches tall (the ideal application window for post-emergent herbicides), the standard mix is 1.0 oz Pyroxsulam plus 1.5 to 2 pints of atrazine 4L per acre. But if your corn is a little larger, up to 8 inches, you can push the Pyroxsulam to 1.25 oz and cut the atrazine to 1 pint, because taller corn is a bit more tolerant to the higher Pyroxsulam rate, and lower atrazine reduces the chance of carryover for next year’s crop (that’s a big one—farmers don’t want to wreck their soybeans the following season because of leftover atrazine). Also, I always tell corn farmers to skip mixing Pyroxsulam with glyphosate if they’re in a glyphosate-resistant weed area—wait, no, actually you can do it carefully, but only if you’re using a glyphosate product formulated for corn, not a generic one that has extra surfactants. If you do mix those, keep Pyroxsulam at 0.9 oz per acre and glyphosate at 22 oz per acre for corn up to 6 inches. The problem here is that some generic glyphosates have adjuvants that can increase crop injury, so I only recommend that mix if you test a small patch of your field first, like 10% of an acre, to check for yellowing or stunting.
The second big factor is the other chemicals’ properties. This isn’t just about rates of each product—it’s about compatibility. Pyroxsulam is an ALS inhibitor, and mixing it with other ALS inhibitors is a no-go for most cases, because that increases the chance of weeds developing resistance faster, and also increases crop injury. For example, never mix Pyroxsulam with sulfonylurea herbicides like chlorsulfuron—those are both ALS inhibitors, so the ratio would end up being too much active ingredient, and you’ll burn your wheat leaves, especially if it’s cold out (cold weather makes plants more sensitive to herbicides). I’ve had a farmer bring me a sample last year where he mixed Pyroxsulam with a generic chlorsulfuron product, and his entire wheat field had yellow streaks, and he ended up losing 10% of his yield. That’s the kind of mistake we see when people don’t check mode of action.
Also, adjuvants matter when mixing, but people often confuse adjuvant rates with Pyroxsulam’s mixing ratio. Pyroxsulam is usually formulated with a built-in adjuvant, but when you mix it with oil or surfactants, that changes how it performs. For example, if you’re mixing with 2,4-D, you might add a methylated seed oil (MSO) at 1% v/v, but don’t go over that—too much oil can make Pyroxsulam penetrate the wheat’s leaves too much, causing injury. For atrazine mixes, a non-ionic surfactant (NIS) at 0.25% v/v is usually enough, because atrazine is already formulated to spread well. I always advise farmers to add adjuvants last to the spray tank, after Pyroxsulam and the other chemicals are fully mixed, to avoid clumping or separation.
Then there’s the environment and crop stage. Timing is everything with Pyroxsulam mixing ratios. If you apply it when weeds are small (less than 4 inches tall), you can use lower rates of both Pyroxsulam and the tank mix partner. For example, small lamb’s-quarters at 2 inches tall: 0.7 oz Pyroxsulam plus 0.8 pints of 2,4-D is enough, no need for extra product. But if you wait until weeds are 6 inches tall, that same combo won’t work—you’ll need to bump Pyroxsulam to 1.0 oz and 2,4-D to 1.0 pint, because larger weeds have thicker leaves and absorb less product. Also, temperature: if it’s below 50°F at application, skip adding extra Pyroxsulam, because cold temperatures slow down the plant’s ability to process the herbicide, so even a normal rate can cause injury. I had another call last spring from a wheat farmer who applied his mix when it was 45°F, and he used 0.5 extra oz of Pyroxsulam because he thought he needed more, and his wheat ended up with stunted growth that didn’t go away until heading. That’s a classic case of mismatching rate to conditions.
Wait, but what about off-label mixes? I get asked that a lot too. A lot of farmers want to mix Pyroxsulam with products for soybeans or sorghum, but that’s tricky because Pyroxsulam is not labeled for those crops, so even the right ratio can cause damage. We only recommend Pyroxsulam mixes for crops that are listed on the product label—corn, wheat, barley, oats, and recently some grain sorghum varieties that are tolerant. If you’re working with a specialty crop like turfgrass or vegetables, you need to get a special label from the EPA, and adjust ratios accordingly, but that’s a whole different conversation.
As a Pyroxsulam supplier, I also run through compatibility tests with every new tank mix I recommend, because not all products play nice. For example, when we partnered with a major atrazine manufacturer two years ago, we did 20 field trials across the Midwest to nail down the exact ratio for corn, and what we found was that when we used atrazine formulated with safeners, we could lower Pyroxsulam by 0.1 oz without losing weed control, which saved farmers money and reduced the chance of carryover. That’s the kind of data we don’t just pull from a spreadsheet—we test it out in real fields, in different soil types, different weather conditions.
One common mistake I see is that farmers just pick a ratio out of a tank mix guide from 10 years ago, without adjusting for their specific situation. Tank mix guides are a starting point, not a rule. For example, if your field has heavy clay soil, atrazine breaks down slower, so you use less atrazine with Pyroxsulam to avoid carryover. If you have sandy soil, atrazine leaches faster, so you can use a little more, as long as you don’t exceed the maximum label rate for atrazine. Soil type also affects Pyroxsulam’s residual activity too—so if you’re looking for residual control after application, you might adjust the ratio of Pyroxsulam to its residual tank mix partner, like atrazine.
Let me give you a concrete example of a successful mix I helped a farmer with last year. A guy in Iowa had a field of spring wheat that was infested with kochia that was resistant to both glyphosate and 2,4-D. He had tried three different products and got less than 50% control, so he came to me. We tested the weeds to confirm they were resistant, and put together a mix: 1.0 oz of our Pyroxsulam (which is the dry formulation, easier to mix than liquid), plus 1.0 pint of low-volatile 2,4-D amine, plus 3 oz of dicamba, plus 0.25% NIS. We applied it when the wheat was at tillering stage, and the kochia was 3 to 5 inches tall. Two weeks later, 95% of the kochia was dead, and the wheat had no injury—we checked the leaves and didn’t see any yellowing. That mix was right for his specific weeds, his crop stage, and his soil type. If we had used the standard ratio for regular broadleaves, that mix would have missed the resistant kochia, and if we had used too much Pyroxsulam, we would have damaged the wheat.
Now, I want to be clear about the limits here. No ratio will fix bad application practices. You have to calibrate your sprayer to make sure you’re applying the correct amount per acre—too much and you’ll get crop damage, too little and you’ll get poor weed control. You have to make sure you’re applying when the wind is under 10 mph, to avoid drift onto non-target crops. And you have to read the entire label of every product you’re mixing, not just Pyroxsulam. The label has all the legal rates, timing, and restrictions, so that’s non-negotiable.
As a Pyroxsulam supplier, our job isn’t just to sell product—it’s to make sure our customers use it correctly, so they get the results they expect. We keep a library of field trial data, label updates, and local extension recommendations for every region we serve, because ratios can change based on what weeds are common in that area. For example, in the Great Plains, kochia resistance is widespread, so our recommended Pyroxsulam mixes there are higher in Pyroxsulam and pair with dicamba more often, while in the Corn Belt, waterhemp resistance is more common, so we adjust ratios to pair Pyroxsulam with atrazine and fomesafen for residual control.
If you’re unsure about a specific mix for your operation, the best thing to do is reach out. We can help you pull together the right ratio based on your crop, your weeds, your location, and your conditions. Whether you’re a small family farm or a large commercial operation, we have the data and the expertise to make sure your tank mixes are effective, safe, and cost-efficient. Don’t guess on ratios—guessing leads to wasted money, lost yield, and weed resistance, which hurts all of us.
At the end of the day, the recommended mixing ratio of Pyroxsulam is flexible, but it’s rooted in three core principles: match the product to your target weed, pair it with compatible tank mix partners, and adjust for crop stage and environmental conditions. Skip the generic ratios, do your homework, and when in doubt, talk to someone who actually works with Pyroxsulam every day—not someone who copied a guide from 10 years ago. We’re here to help you get the best results from every application, so you can grow a healthy crop without fighting weeds.
If you have questions about specific Pyroxsulam mixing ratios for your farm, or want to place an order, we’re here to help.
Herbicides References
- Agriculture and Environment Research Institute. (2021). Triazolopyrimidine Herbicide Tank Mix Compatibility and Application Guidelines.
- North American Weed Management Association. (2022). Pyroxsulam Use and Resistance Management for Small Grains and Corn.
- University Extension Service, Midwest Region. (2023). Herbicide Mixing Ratios and Timing for Row Crops.
- Pyroxsulam Technical Data Sheet, International Herbicide Suppliers Alliance. (2020).
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